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Universiteit Leiden

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1988

Dingemanse, J., Polhuijs, M., Danhof, M. , Altered pharmacokinetic-pharmacodynamic relationship of heptabarbital in experimental renal failure in rats, J Pharmacol Exp Ther, vol. 246, no. 1, pp. 371-6.

Koopmans, R., Dingemanse, J., Danhof, M., Horsten, G.P., van Boxtel, C.J. , Pharmacokinetic-pharmacodynamic modeling of midazolam effects on the human central nervous system, Clin Pharmacol Ther, vol. 44, no. 1, pp. 14-22. DOI

van Bree, J.B., de Boer, A.G., Danhof, M., Ginsel, L.A., Breimer, D.D. , Characterization of an "in vitro" blood-brain barrier: effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs, J Pharmacol Exp Ther, vol. 247, no. 3, pp. 1233-9.

Dingemanse, J., Thomassen, D., Mentink, B.H., Danhof, M. , Strategy to assess the role of (inter)active metabolites in pharmacodynamic studies in-vivo: a model study with heptabarbital, J Pharm Pharmacol, vol. 40, no. 8, pp. 552-7.

Dingemanse, J., Sollie, F.A., Breimer, D.D., Danhof, M. , Pharmacokinetic modeling of the anticonvulsant response of oxazepam in rats using the pentylenetetrazol threshold concentration as pharmacodynamic measure, J Pharmacokinet Biopharm, vol. 16, no. 2, pp. 203-28.

Dingemanse, J., Danhof, M., Breimer, D.D. , Pharmacokinetic-pharmacodynamic modeling of CNS drug effects: an overview, Pharmacol Ther, vol. 38, no. 1, pp. 1-52. DOI

1987

Posner, J., Danhof, M., Teunissen, M.W., Breimer, D.D., Whiteman, P.D. , The disposition of antipyrine and its metabolites in young and elderly healthy volunteers, Br J Clin Pharmacol, vol. 24, no. 1, pp. 51-5.

Kleinbloesem, C.H., van Brummelen, P., Danhof, M., Faber, H., Urquhart, J., Breimer, D.D. , Rate of increase in the plasma concentration of nifedipine as a major determinant of its hemodynamic effects in humans, Clin Pharmacol Ther, vol. 41, no. 1, pp. 26-30. DOI

van Harten, J., Burggraaf, K., Danhof, M., van Brummelen, P., Breimer, D.D. , Negligible sublingual absorption of nifedipine, Lancet, vol. 2, no. 8572, pp. 1363-5.

1986

Lequin, R.M., van den Boogaard, A., Vermeulen, J., Danhof, M. , Progesterone in saliva: pitfalls and consequent implications for accuracy of the determination, Clin Chem, vol. 32, no. 5, pp. 831-4.

Kleinbloesem, C.H., van Harten, J., Wilson, J.P., Danhof, M., van Brummelen, P., Breimer, D.D. , Nifedipine: kinetics and hemodynamic effects in patients with liver cirrhosis after intravenous and oral administration, Clin Pharmacol Ther, vol. 40, no. 1, pp. 21-8. DOI

1985

Kleinbloesem, C.H., van Brummelen, P., van Harten, J., Danhof, M., Breimer, D.D. , Nifedipine: influence of renal function on pharmacokinetic/hemodynamic relationship, Clin Pharmacol Ther, vol. 37, no. 5, pp. 563-74. DOI

Danhof, M., Hisaoka, M., Levy, G. , Kinetics of drug action in disease states XII: Effect of experimental liver diseases on the pharmacodynamics of phenobarbital and ethanol in rats, J Pharm Sci, vol. 74, no. 3, pp. 321-4.

Hisaoka, M., Danhof, M., Levy, G. , Kinetics of drug action in disease states. VII. Effect of experimental renal dysfunction on the pharmacodynamics of ethanol in rats, J Pharmacol Exp Ther, vol. 232, no. 3, pp. 717-21.

Danhof, M., Hisaoka, M., Levy, G. , Kinetics of drug action in disease states. VI. Effect of experimental diabetes on phenobarbital concentrations in rats at onset of loss of righting reflex, J Pharmacol Exp Ther, vol. 232, no. 2, pp. 435-8.

Danhof, M., Levy, G. , Kinetics of drug action in disease states. IV. Effect of pregnancy on phenobarbital concentrations at onset of loss of righting reflex in rats, J Pharmacol Exp Ther, vol. 232, no. 2, pp. 426-9.

Danhof, M., Levy, G. , Kinetics of drug action in disease states. V. Acute effect of urea infusion on phenobarbital concentrations in rats at onset of loss of righting reflex, J Pharmacol Exp Ther, vol. 232, no. 2, pp. 430-4.

1984

Danhof, M., Hisaoka, M., Levy, G. , Kinetics of drug action in disease states. II. Effect of experimental renal dysfunction on phenobarbital concentrations in rats at onset of loss of righting reflect, J Pharmacol Exp Ther, vol. 230, no. 3, pp. 627-31.

Kleinbloesem, C.H., van Brummelen, P., Faber, H., Danhof, M., Vermeulen, N.P., Breimer, D.D. , Variability in nifedipine pharmacokinetics and dynamics: a new oxidation polymorphism in man, Biochem Pharmacol, vol. 33, no. 22, pp. 3721-4. DOI

Humphries, E.H., Danhof, M.L., Hlozanek, I , Characterization of endogenous viral loci in five lines of white Leghorn chickens, Virology, vol. 135, no. 1, pp. 125-38.

Danhof, M., Levy, G. , Kinetics of drug action in disease states. I. Effect of infusion rate on phenobarbital concentrations in serum, brain and cerebrospinal fluid of normal rats at onset of loss of righting reflex, J Pharmacol Exp Ther, vol. 229, no. 1, pp. 44-50.

1983

Vermeulen, N.P., Danhof, M., Setiawan, I, Breimer, D.D. , Disposition of hexobarbital in the rat. Estimation of "first-pass" elimination and influence of ether anesthesia, J Pharmacol Exp Ther, vol. 226, no. 1, pp. 201-5.

1982

Danhof, M., Verbeek, R.M., van Boxtel, C.J., Boeijinga, J.K., Breimer, D.D. , Differential effects of enzyme induction on antipyrine metabolite formation, Br J Clin Pharmacol, vol. 13, no. 3, pp. 379-86.

Danhof, M., Teunissen, M.W., Breimer, D.D. , 3-Hydroxymethyl antipyrine excretion in urine after an oral dose of antipyrine. A reconsideration of previously published data and synthesis of a pure reference substance, Pharmacology, vol. 24, no. 3, pp. 181-4.

Danhof, M., van Zuilen, A., Boeijinga, J.K., Breimer, D.D. , Studies of the different metabolic pathways of antipyrine in man. Oral versus i.v. administration and the influence of urinary collection time, Eur J Clin Pharmacol, vol. 21, no. 5, pp. 433-41.

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