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2008
van Steeg, T.J., Freijer, J., Danhof, M., de Lange, E.C. , Mechanism-based pharmacodynamic modeling of S(-)-atenolol: estimation of in vivo affinity for the beta1-adrenoceptor with an agonist-antagonist interaction model, J Pharmacol Exp Ther, vol. 324, no. 3, pp. 1234-42. DOI
2007
Zuideveld, K.P., Van der Graaf, P.H., Peletier, L.A., Danhof, M. , Allometric scaling of pharmacodynamic responses: application to 5-Ht1A receptor mediated responses from rat to man, Pharm Res, vol. 24, no. 11, pp. 2031-9. DOI
Danhof, M., de Jongh, J., De Lange, E.C., Della Pasqua, O., Ploeger, B.A., Voskuyl, R.A. , Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis, Annu Rev Pharmacol Toxicol, vol. 47, pp. 357-400. DOI
2006
van Dorp, E., Yassen, A., Sarton, E., Romberg, R., Olofsen, E., Teppema, L., Danhof, M., Dahan, A. , Naloxone reversal of buprenorphine-induced respiratory depression, Anesthesiology, vol. 105, no. 1, pp. 51-7. DOI
2005
Liefaard, L.C., Ploeger, B.A., Molthoff, C.F., Boellaard, R., Lammertsma, A.A., Danhof, M., Voskuyl, R.A. , Population pharmacokinetic analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography, Mol Imaging Biol, vol. 7, no. 6, pp. 411-21. DOI
Yassen, A., Olofsen, E., Dahan, A., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics, J Pharmacol Exp Ther, vol. 313, no. 3, pp. 1136-49. DOI
2004
Zuideveld, K.P., Van der Graaf, P.H., Newgreen, D., Thurlow, R., Petty, N., Jordan, P., Peletier, L.A., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of 5-HT1A receptor agonists: estimation of in vivo affinity and intrinsic efficacy on body temperature in rats, J Pharmacol Exp Ther, vol. 308, no. 3, pp. 1012-20. DOI
2003
Schaddelee, M.P., Voorwinden, H.L., Groenendaal, D., Hersey, A., Ijzerman, A.P., Danhof, M., De Boer, A.G. , Blood-brain barrier transport of synthetic adenosine A1 receptor agonists in vitro: structure transport relationships, Eur J Pharm Sci, vol. 20, no. 3, pp. 347-56. DOI
Bueters, T.J., van Helden, H.P., AP, I.J., Danhof, M. , Low efficacy adenosine A1 agonists inhibit striatal acetylcholine release in rats improving central selectivity of action, Neurosci Lett, vol. 343, no. 1, pp. 57-61. DOI
Visser, S.A., Wolters, F.L., van der Graaf, P.H., Peletier, L.A., Danhof, M. , Dose-dependent EEG effects of zolpidem provide evidence for GABA(A) receptor subtype selectivity in vivo, J Pharmacol Exp Ther, vol. 304, no. 3, pp. 1251-7. DOI
2002
Bueters, T.J., van Helden, H.P., Danhof, M., AP, I.J. , Effects of the adenosine A1 receptor allosteric modulators PD 81,723 and LUF 5484 on the striatal acetylcholine release, Eur J Pharmacol, vol. 454, no. 2-3, pp. 177-82. DOI
Zuideveld, K.P., van Gestel, A., Peletier, L.A., Van der Graaf, P.H., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the hypothermic and corticosterone effects of the 5-HT1A receptor agonist flesinoxan, Eur J Pharmacol, vol. 445, no. 1-2, pp. 43-54. DOI
Zuideveld, K.P., Rusic-Pavletic, J., Maas, H.J., Peletier, L.A., Van der Graaf, P.H., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in rats, J Pharmacol Exp Ther, vol. 303, no. 3, pp. 1130-7. DOI
Danhof, M. , Electroencephalography parameters as biomarkers: extrapolation from laboratory animals to humans, Methods Find Exp Clin Pharmacol, vol. 24 Suppl D, pp. 63-4. DOI
2001
Vis, P., Della Pasqua, O., Kruk, M., Martin, D., Mocaer, E., Danhof, M., Jochemsen, R. , Population pharmacokinetic-pharmacodynamic modelling of S 15535, a 5-HT(1A) receptor agonist, using a behavioural model in rats, Eur J Pharmacol, vol. 414, no. 2-3, pp. 233-43. DOI
2000
1999
Van der Graaf, P.H., Nilsson, J., Van Schaick, E.A., Danhof, M. , Multivariate quantitative structure-pharmacokinetic relationships (QSPKR) analysis of adenosine A1 receptor agonists in rat, J Pharm Sci, vol. 88, no. 3, pp. 306-12. DOI
1998
Cox, E.H., Kerbusch, T., Van der Graaf, P.H., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: correlation with the interaction at the mu-opioid receptor, J Pharmacol Exp Ther, vol. 284, no. 3, pp. 1095-103.
1997
Van der Graaf, P.H., Danhof, M. , Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling, Int J Clin Pharmacol Ther, vol. 35, no. 10, pp. 442-6.
Van Schaick, E.A., Math-ot, R.A., Gubbens-Stibbe, J.M., Langemeijer, M.W., Roelen, H.C., Ijzerman, A.P., Danhof, M. , 8-Alkylamino-substituted analogs of N6-cyclopentyladenosine are partial agonists for the cardiovascular adenosine A1 receptors in vivo, J Pharmacol Exp Ther, vol. 283, no. 2, pp. 800-8.
1996
Hoogerkamp, A., Arends, R.H., Bomers, A.M., Mandema, J.W., Voskuyl, R.A., Danhof, M. , Pharmacokinetic/pharmacodynamic relationship of benzodiazepines in the direct cortical stimulation model of anticonvulsant effect, J Pharmacol Exp Ther, vol. 279, no. 2, pp. 803-12.
Mathoot, R.A., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo, Br J Pharmacol, vol. 118, no. 2, pp. 369-77.
Van Schaick, E.A., Jacobson, K.A., Kim, H.O., AP, I.J., Danhof, M. , Hemodynamic effects and histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious rats, Eur J Pharmacol, vol. 308, no. 3, pp. 311-4. DOI
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