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Filters: keyword is Anticonvulsants  [Clear All Filters]
2008
Clinckers, R., Smolders, I, Michotte, Y., Ebinger, G., Danhof, M., Voskuyl, R.A., Della Pasqua, O. , Impact of efflux transporters and of seizures on the pharmacokinetics of oxcarbazepine metabolite in the rat brain, Br J Pharmacol, vol. 155, no. 7, pp. 1127-38. DOI
2007
Jonker, D.M., Voskuyl, R.A., Danhof, M. , Synergistic combinations of anticonvulsant agents: what is the evidence from animal experiments?, Epilepsia, vol. 48, no. 3, pp. 412-34. DOI
2004
Jonker, D.M., Voskuyl, R.A., Danhof, M. , Pharmacodynamic analysis of the anticonvulsant effects of tiagabine and lamotrigine in combination in the rat, Epilepsia, vol. 45, no. 5, pp. 424-35. DOI
2003
Jonker, D.M., van de Mheen, C., Eilers, P.H., Kruk, M.R., Voskuyl, R.A., Danhof, M. , Anticonvulsant drugs differentially suppress individual ictal signs: a pharmacokinetic/pharmacodynamic analysis in the cortical stimulation model in the rat, Behav Neurosci, vol. 117, no. 5, pp. 1076-85. DOI
Jonker, D.M., Vermeij, D.A., Edelbroek, P.M., Voskuyl, R.A., Piotrovsky, V.K., Danhof, M. , Pharmacodynamic analysis of the interaction between tiagabine and midazolam with an allosteric model that incorporates signal transduction, Epilepsia, vol. 44, no. 3, pp. 329-38. DOI
2000
Della Paschoa, O.E., Hoogerkamp, A., Edelbroek, P.M., Voskuyl, R.A., Danhof, M. , Pharmacokinetic-pharmacodynamic correlation of lamotrigine, flunarizine, loreclezole, CGP40116 and CGP39551 in the cortical stimulation model, Epilepsy Res, vol. 40, no. 1, pp. 41-52. DOI
Cleton, A., Altorf, B.A., Voskuyl, R.A., Danhof, M. , Effect of amygdala kindling on the central nervous system effects of tiagabine: EEG effects versus brain GABA levels, Br J Pharmacol, vol. 130, no. 5, pp. 1037-44. DOI
1999
Cleton, A., Van der Graaf, P.H., Ghijsen, W., Voskuyl, R., Danhof, M. , Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy, Pharm Res, vol. 16, no. 11, pp. 1702-9.
1998
Della Paschoa, O.E., Kruk, M.R., Hamstra, R., Voskuyl, R.A., Danhof, M. , Pharmacodynamic interaction between phenytoin and sodium valproate changes seizure thresholds and pattern, Br J Pharmacol, vol. 125, no. 5, pp. 997-1004. DOI
Della Paschoa, O.E., Mandema, J.W., Voskuyl, R.A., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the anticonvulsant and electroencephalogram effects of phenytoin in rats, J Pharmacol Exp Ther, vol. 284, no. 2, pp. 460-6.
Della Paschoa, O.E., Kruk, M.R., Voskuyl, R.A., Danhof, M. , Effects of repeated seizure induction on seizure activity, post-ictal and interictal behavior, Brain Res, vol. 814, no. 1-2, pp. 199-208. DOI
Della Paschoa, O.E., Voskuyl, R.A., Danhof, M. , Modelling of the pharmacodynamic interaction between phenytoin and sodium valproate, Br J Pharmacol, vol. 125, no. 7, pp. 1610-6. DOI
1996
Hoogerkamp, A., Arends, R.H., Bomers, A.M., Mandema, J.W., Voskuyl, R.A., Danhof, M. , Pharmacokinetic/pharmacodynamic relationship of benzodiazepines in the direct cortical stimulation model of anticonvulsant effect, J Pharmacol Exp Ther, vol. 279, no. 2, pp. 803-12.
1994
Hoogerkamp, A., Vis, P.W., Danhof, M., Voskuyl, R.A. , Characterization of the pharmacodynamics of several antiepileptic drugs in a direct cortical stimulation model of anticonvulsant effect in the rat, J Pharmacol Exp Ther, vol. 269, no. 2, pp. 521-8.
1993
Stijnen, A.M., Hovinga, S., Langemeijer, M.W., Hoogerkamp, A., van Bezooijen, C.F., Danhof, M. , Increased sensitivity to the anticonvulsant effect of valproate in aging BN/BiRij rats, Pharm Res, vol. 10, no. 7, pp. 1046-51.
1992
Stijnen, A.M., Postel-Westra, I, Langemeijer, M.W., Hoogerkamp, A., Voskuyl, R.A., van Bezooijen, C.F., Danhof, M. , Pharmacodynamics of the anticonvulsant effect of oxazepam in aging BN/BiRij rats, Br J Pharmacol, vol. 107, no. 1, pp. 165-70.
Voskuyl, R.A., Hoogerkamp, A., Danhof, M. , Properties of the convulsive threshold determined by direct cortical stimulation in rats, Epilepsy Res, vol. 12, no. 2, pp. 111-20.
1991
Mandema, J.W., Sansom, L.N., Dios-Vieitez, M.C., Hollander-Jansen, M., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the electroencephalographic effects of benzodiazepines. Correlation with receptor binding and anticonvulsant activity, J Pharmacol Exp Ther, vol. 257, no. 1, pp. 472-8.
1990
Dingemanse, J., Hameter, B.M., Danhof, M. , Pharmacodynamics of tolerance development to the anesthetic and anticonvulsant effects of phenobarbital in rats, J Pharm Sci, vol. 79, no. 3, pp. 207-11.
Dingemanse, J., Voskuyl, R.A., Langemeijer, M.W., Postel-Westra, I, Breimer, D.D., Meinardi, H., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the anticonvulsant effect of oxazepam in individual rats, Br J Pharmacol, vol. 99, no. 1, pp. 53-8.
1989
Hollander-Jansen, M., Dingemanse, J., Langemeijer, M.W., Danhof, M. , Relationship between receptor occupancy at 37 degrees C and the anticonvulsant effect of flunitrazepam in rats, Pharm Res, vol. 6, no. 7, pp. 585-91.
1988
Dingemanse, J., Sollie, F.A., Breimer, D.D., Danhof, M. , Pharmacokinetic modeling of the anticonvulsant response of oxazepam in rats using the pentylenetetrazol threshold concentration as pharmacodynamic measure, J Pharmacokinet Biopharm, vol. 16, no. 2, pp. 203-28.