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2008
Ravenstijn, P.G., Merlini, M., Hameetman, M., Murray, T.K., Ward, M.A., Lewis, H., Ball, G., Mottart, C., de Ville Goyet, C., Lemarchand, T., van Belle, K., O'Neill, M.J., Danhof, M., de Lange, E.C. , The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK-PD experiments, J Pharmacol Toxicol Methods, vol. 57, no. 2, pp. 114-30. DOI
van Steeg, T.J., Freijer, J., Danhof, M., de Lange, E.C. , Mechanism-based pharmacodynamic modeling of S(-)-atenolol: estimation of in vivo affinity for the beta1-adrenoceptor with an agonist-antagonist interaction model, J Pharmacol Exp Ther, vol. 324, no. 3, pp. 1234-42. DOI
Groenendaal, D., Freijer, J., Rosier, A., de Mik, D., Nicholls, G., Hersey, A., Ayrton, A.D., Danhof, M., de Lange, E.C. , Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: the role of complex biophase distribution kinetics, Eur J Pharm Sci, vol. 34, no. 2-3, pp. 149-63. DOI
van Steeg, T.J., Boralli, V.B., Krekels, E.H., Slijkerman, P., Freijer, J., Danhof, M., de Lange, E.C. , Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach, J Pharm Sci. DOI
Danhof, M., de Lange, E.C., Della Pasqua, O.E., Ploeger, B.A., Voskuyl, R.A. , Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research, Trends Pharmacol Sci, vol. 29, no. 4, pp. 186-91. DOI
2007
van Steeg, T.J., Freijer, J., Danhof, M., de Lange, E.C. , Pharmacokinetic-pharmacodynamic modelling of S(-)-atenolol in rats: reduction of isoprenaline-induced tachycardia as a continuous pharmacodynamic endpoint, Br J Pharmacol, vol. 151, no. 3, pp. 356-66. DOI
van Steeg, T.J., Krekels, E.H., Danhof, M., de Lange, E.C. , Reproducible and time-dependent modification of serum protein binding in Wistar Kyoto rats, J Pharmacol Toxicol Methods, vol. 56, no. 1, pp. 72-8. DOI
Groenendaal, D., Freijer, J., de Mik, D., Bouw, M.R., Danhof, M., de Lange, E.C. , Influence of biophase distribution and P-glycoprotein interaction on pharmacokinetic-pharmacodynamic modelling of the effects of morphine on the EEG, Br J Pharmacol, vol. 151, no. 5, pp. 713-20. DOI
Groenendaal, D., Freijer, J., de Mik, D., Bouw, M.R., Danhof, M., de Lange, E.C. , Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux, Br J Pharmacol, vol. 151, no. 5, pp. 701-12. DOI
Danhof, M., de Jongh, J., De Lange, E.C., Della Pasqua, O., Ploeger, B.A., Voskuyl, R.A. , Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis, Annu Rev Pharmacol Toxicol, vol. 47, pp. 357-400. DOI
2002
1997
de Lange, E.C., Danhof, M., de Boer, A.G., Breimer, D.D. , Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier, Brain Res Brain Res Rev, vol. 25, no. 1, pp. 27-49. DOI
1995
de Lange, E.C., Bouw, M.R., Mandema, J.W., Danhof, M., de Boer, A.G., Breimer, D.D. , Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brain, Br J Pharmacol, vol. 116, no. 5, pp. 2538-44.
de Lange, E.C., Hesselink, M.B., Danhof, M., de Boer, A.G., Breimer, D.D. , The use of intracerebral microdialysis to determine changes in blood-brain barrier transport characteristics, Pharm Res, vol. 12, no. 1, pp. 129-33.
de Lange, E.C., Danhof, M., Zurcher, C., de Boer, A.G., Breimer, D.D. , Repeated microdialysis perfusions: periprobe tissue reactions and BBB permeability, Brain Res, vol. 702, no. 1-2, pp. 261-5. DOI
de Lange, E.C., de Vries, J.D., Zurcher, C., Danhof, M., de Boer, A.G., Breimer, D.D. , The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain, Pharm Res, vol. 12, no. 12, pp. 1924-31.
1994
de Lange, E.C., Danhof, M., de Boer, A.G., Breimer, D.D. , Critical factors of intracerebral microdialysis as a technique to determine the pharmacokinetics of drugs in rat brain, Brain Res, vol. 666, no. 1, pp. 1-8.
1993
de Lange, E.C., Danhof, M., de Boer, A.G., Breimer, D.D. , The use of intracerebral microdialysis to study blood-brain barrier transport in health, after modification and in disease, Adv Exp Med Biol, vol. 331, pp. 257-62.