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2008
Yassen, A., Olofsen, E., Kan, J., Dahan, A., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats, Pharm Res, vol. 25, no. 1, pp. 183-93. DOI
2007
Yassen, A., Kan, J., Olofsen, E., Suidgeest, E., Dahan, A., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of norbuprenorphine in rats, J Pharmacol Exp Ther, vol. 321, no. 2, pp. 598-607. DOI
Yassen, A., Olofsen, E., Romberg, R., Sarton, E., Teppema, L., Danhof, M., Dahan, A. , Mechanism-based PK/PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in healthy volunteers, Clin Pharmacol Ther, vol. 81, no. 1, pp. 50-8. DOI
Yassen, A., Olofsen, E., Kan, J., Dahan, A., Danhof, M. , Animal-to-human extrapolation of the pharmacokinetic and pharmacodynamic properties of buprenorphine, Clin Pharmacokinet, vol. 46, no. 5, pp. 433-47. DOI
Yassen, A., Olofsen, E., van Dorp, E., Sarton, E., Teppema, L., Danhof, M., Dahan, A. , Mechanism-based pharmacokinetic-pharmacodynamic modelling of the reversal of buprenorphine-induced respiratory depression by naloxone : a study in healthy volunteers, Clin Pharmacokinet, vol. 46, no. 11, pp. 965-80. DOI
2006
Yassen, A., Kan, J., Olofsen, E., Suidgeest, E., Dahan, A., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of the respiratory-depressant effect of buprenorphine and fentanyl in rats, J Pharmacol Exp Ther, vol. 319, no. 2, pp. 682-92. DOI
Dahan, A., Yassen, A., Romberg, R., Sarton, E., Teppema, L., Olofsen, E., Danhof, M. , Buprenorphine induces ceiling in respiratory depression but not in analgesia, Br J Anaesth, vol. 96, no. 5, pp. 627-32. DOI
Yassen, A., Olofsen, E., Romberg, R., Sarton, E., Danhof, M., Dahan, A. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine in healthy volunteers, Anesthesiology, vol. 104, no. 6, pp. 1232-42. DOI
van Dorp, E., Yassen, A., Sarton, E., Romberg, R., Olofsen, E., Teppema, L., Danhof, M., Dahan, A. , Naloxone reversal of buprenorphine-induced respiratory depression, Anesthesiology, vol. 105, no. 1, pp. 51-7. DOI
2005
Dahan, A., Yassen, A., Bijl, H., Romberg, R., Sarton, E., Teppema, L., Olofsen, E., Danhof, M. , Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats, Br J Anaesth, vol. 94, no. 6, pp. 825-34. DOI
Yassen, A., Olofsen, E., Dahan, A., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics, J Pharmacol Exp Ther, vol. 313, no. 3, pp. 1136-49. DOI