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2004
Schaddelee, M.P., Groenendaal, D., DeJongh, J., Cleypool, C.G., AP, I.J., De Boer, A.G., Danhof, M. , Population pharmacokinetic modeling of blood-brain barrier transport of synthetic adenosine A1 receptor agonists, J Pharmacol Exp Ther, vol. 311, no. 3, pp. 1138-46. DOI
2003
Bueters, T.J., van Duivenvoorde, L.M., Danhof, M., AP, I.J., van Helden, H.P. , Cyclopentyladenosine and some of its low-efficacy derivatives inhibit striatal synaptosomal release of acetylcholine to a similar degree, Eur J Pharmacol, vol. 481, no. 2-3, pp. 141-6. DOI
Bueters, T.J., van Helden, H.P., AP, I.J., Danhof, M. , Low efficacy adenosine A1 agonists inhibit striatal acetylcholine release in rats improving central selectivity of action, Neurosci Lett, vol. 343, no. 1, pp. 57-61. DOI
2002
Bueters, T.J., van Helden, H.P., Danhof, M., AP, I.J. , Effects of the adenosine A1 receptor allosteric modulators PD 81,723 and LUF 5484 on the striatal acetylcholine release, Eur J Pharmacol, vol. 454, no. 2-3, pp. 177-82. DOI
Bueters, T.J., Groen, B., Danhof, M., AP, I.J., Van Helden, H.P. , Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication, Arch Toxicol, vol. 76, no. 11, pp. 650-6. DOI
1998
van Schaick, E.A., Tukker, H.E., Roelen, H.C., AP, I.J., Danhof, M. , Selectivity of action of 8-alkylamino analogues of N6-cyclopentyladenosine in vivo: haemodynamic versus anti-lipolytic responses in rats, Br J Pharmacol, vol. 124, no. 3, pp. 607-18. DOI
1997
van Schaick, E.A., de Greef, H.J., Langemeijer, M.W., Sheehan, M.J., AP, I.J., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the anti-lipolytic and anti-ketotic effects of the adenosine A1-receptor agonist N6-(p-sulphophenyl)adenosine in rats, Br J Pharmacol, vol. 122, no. 3, pp. 525-33. DOI
Bol, C.J., AP, I.J., Danhof, M., Mandema, J.W. , Determination of dexmedetomidine in rat plasma by a sensitive [3H]clonidine radioreceptor assay, J Pharm Sci, vol. 86, no. 7, pp. 822-6. DOI
van Schaick, E.A., Kulkarni, C., von Frijtag Drabbe Kunzel, J.K., Mathot, R.A., Cristalli, G., AP, I.J., Danhof, M. , Time course of action of three adenosine A1 receptor agonists with differing lipophilicity in rats: comparison of pharmacokinetic, haemodynamic and EEG effects, Naunyn Schmiedebergs Arch Pharmacol, vol. 356, no. 6, pp. 827-37.
1996
Van Schaick, E.A., Jacobson, K.A., Kim, H.O., AP, I.J., Danhof, M. , Hemodynamic effects and histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious rats, Eur J Pharmacol, vol. 308, no. 3, pp. 311-4. DOI
1995
van der Wenden, E.M., von Frijtag Drabbe Kunzel, J.K., Mathot, R.A., Danhof, M., AP, I.J., Soudijn, W. , Ribose-modified adenosine analogues as potential partial agonists for the adenosine receptor, J Med Chem, vol. 38, no. 20, pp. 4000-6.
Mathot, R.A., Van der Wenden, E.M., Soudijn, W., AP, I.J., Danhof, M. , Deoxyribose analogues of N6-cyclopentyladenosine (CPA): partial agonists at the adenosine A1 receptor in vivo, Br J Pharmacol, vol. 116, no. 3, pp. 1957-64.
Mathot, R.A., Cleton, A., Soudijn, W., AP, I.J., Danhof, M. , Pharmacokinetic modelling of the haemodynamic effects of the A2a adenosine receptor agonist CGS 21680C in conscious normotensive rats, Br J Pharmacol, vol. 114, no. 4, pp. 761-8.
Van der Wenden, E.M., Hartog-Witte, H.R., Roelen, H.C., von Frijtag Drabbe Kunzel, J.K., Pirovano, I.M., Mathot, R.A., Danhof, M., Van Aerschot, A., Lidaks, M.J., AP, I.J., , . et al., 8-substituted adenosine and theophylline-7-riboside analogues as potential partial agonists for the adenosine A1 receptor, Eur J Pharmacol, vol. 290, no. 3, pp. 189-99.
Appel, S., Mathot, R.A., Langemeijer, M.W., AP, I.J., Danhof, M. , Modelling of the pharmacodynamic interaction of an A1 adenosine receptor agonist and antagonist in vivo: N6-cyclopentyladenosine and 8-cyclopentyltheophylline, Br J Pharmacol, vol. 115, no. 7, pp. 1253-9.
1994
AP, I.J., van der Wenden, E.M., von Frijtag Drabbe Kunzel, J.K., Mathot, R.A., Danhof, M., Borea, P.A., Varani, K. , Partial agonism of theophylline-7-riboside on adenosine receptors, Naunyn Schmiedebergs Arch Pharmacol, vol. 350, no. 6, pp. 638-45.
Irth, H., Cleton, A., Mathot, R.A., Danhof, M., AP, I.J., Tjaden, U.R., van der Greef, J. , Liquid chromatographic determination of the adenosine receptor agonist CGS 21680 in blood using on-line solid-phase extraction on a phenylboronic acid support and fluorescence detection, J Chromatogr B Biomed Appl, vol. 658, no. 1, pp. 207-12.
1993